14 Aug Biostats HW
Homework 1
Question 1
a) What is probability of observing 61325 when rolling fair dice?
Probabilities for fair dice: P(1)=P(2)=P(3)=P(4)=P(5)=P(6)=1/6
b) What is probability of observing 61325 when rolling loaded dice?
Probabilities for fair dice: P(1)=P(2)=P(3)=P(4)=P(5)= 0.1 and P(6)=0.5
Question 2
On a hypothetical island virus outbreak becomes a threat of future pandemic. Researchers have narrowed down the cause of outbreak to two viruses (virus 1 and virus 2). The DNA sequencing lab receives a sample for further analysis. Unfortunately, the sample was contaminated and the removal of foreign DNA leaves the lab with a short DNA fragment: AGTAGCTTCCAG. Given all available information (provided below) how can lab determine the type of the virus that caused the outbreak.
Nucleotide probabilities of virus1
P(A)=P(T) =0.3
P(G)=P(C) = 0.2
Nucleotide probabilities of virus 2
P(A)=P(T)=P(G)=P(C)= .25
Assume:
– Virus 1 and Virus 2 are equally likely to occur in nature.
– nucleotides are independent and identically distributed.
Question 3
Align two sequences shown below using Needelman Wunsch algorithm.
Use match score of 4, mismatch score of -4 and gap penalty score of -2.
Show:
a) dynamic programming matrix with scores (as it shown in Figure 6.1, Ewens or in Figure 2.5, Durbin which is available under Course Content.)
b) trace back pointers
c) alignment score
sequences:
sequence 1:
AGAGCTCACAA
sequence 2:
AGTAGCTTCCAAA
Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Ask A Question and we will direct you to our Order Page at WriteDemy. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.
About Wridemy
We are a professional paper writing website. If you have searched a question and bumped into our website just know you are in the right place to get help in your coursework. We offer HIGH QUALITY & PLAGIARISM FREE Papers.
How It Works
To make an Order you only need to click on “Place Order” and we will direct you to our Order Page. Fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Are there Discounts?
All new clients are eligible for 20% off in their first Order. Our payment method is safe and secure.